Plasmid-encoded OXA-48 carbapenemase in Escherichia coli from Israel
نویسندگان
چکیده
منابع مشابه
Escherichia coli from Italy producing OXA-48 carbapenemase encoded by a novel Tn1999 transposon derivative.
OXA-48 is an emerging class D carbapenemase originally identified in isolates from Turkey (14) and subsequently detected in several European and north African countries (10). Klebsiella pneumoniae is the most common host for OXA-48, but the enzyme has also been detected in Escherichia coli and Enterobacter cloacae (10). The blaOXA-48 gene is carried by the composite transposon Tn1999 or a varia...
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OBJECTIVES To evaluate the possible occurrence of carbapenemase-producing Escherichia coli and Klebsiella spp. strains in domestic animals. METHODS Veterinary clinical E. coli (n = 1175) and Klebsiella spp. (n = 136) isolates consecutively collected from livestock and companion animals in Germany from June 2012 to October 2012 were screened for their susceptibility to carbapenems using the ag...
متن کاملPrevalence of plasmid-encoded carbapenemases in multi-drug resistant Escherichia coli from patients with urinary tract infection in northern Iran
Objective(s): Resistance to carbapenems as the last line for controlling resistant bacteria is increasing due to production of carbapenemase. The aim of this study was to detect the plasmid-encoded carbapenemases using phenotypic methods and multiplex PCR among the multi-drug resistant (MDR) isolates from patients with urinary tract infection (UTI) in northern Iran.<br...
متن کاملDetection of OXA-48 carbapenemase in the pandemic clone Escherichia coli O25b:H4-ST131 in the course of investigation of an outbreak of OXA-48-producing Klebsiella pneumoniae.
Reports of carbapenemase-producing Enterobacteriaceae (CPE) have increased dramatically in the past decade. OXA-48 was first described in Turkey in 2008, and outbreaks of OXA-48-producing Enterobacteriaceae have since been reported worldwide, including Ireland (3, 12, 16). Escherichia coli O25b:H4-ST131 is a very successful uropathogenic clonal group, and its close association with the extended...
متن کاملDerepressed transfer properties leading to the efficient spread of the plasmid encoding carbapenemase OXA-48.
The current emergence of the carbapenemase OXA-48 among Enterobacteriaceae is related to the spread of a single IncL/M-type plasmid, pOXA-48a. This plasmid harbors the blaOXA-48 gene within a composite transposon, Tn1999, which is inserted into the tir gene, encoding a transfer inhibition protein. We showed that the insertion of Tn1999 into the tir gene was involved in a higher transfer frequen...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2010
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/dkq467